Programma

5 Novembre

14.00-15.30

OPENING CEREMONY

14.00 Official opening of the congress

Carlo Ferrarese

14.10 Le Demenze al tempo del Covid

Amalia Cecilia Bruni

14.25 Airalzh awards

14.30 Greetings from presidents SIN, AIP, SINeG, AINAT, SIMG

15.00 Inaugural Massimo Musicco Lecture

Striving for a world without dementia: Lessons and hopes from decades of clinico-epidemiological research Chairperson: Carlo Ferrarese

Speaker: Laura Fratiglioni

15.30-17.00

SYMPOSIUM

Immunoterapia: stato dell’arte

with unrestricted grant by Biogen

Chairpersons: Carlo Ferrarese and Gianluigi Forloni

15.30 La via della beta-amiloide Alessandro Padovani

16.15 La via della tau

Fabrizio Tagliavini

17.00-18.30

SCIENTIFIC SESSION 1

Neuroimaging challenges: a case-based workshop promoted by SINDEM Neuroimaging in Dementia Study Group with unrestricted grant by Novartis

Chairpersons: Federica Agosta and Massimo Filippi

17.00 How to read MRI in patients with rapid cognitive impairment

Bastiaan Moraal

17.20 What can “white matter lesions” tell us about the disease? Mike Wattjes

17.40 MRI as magnifying glass in focal dementias Federica Agosta

ORAL COMMUNICATIONS

Chairpersons: Marco Bozzali and Daniela Perani

18.00 MRI signal reduction in the ventral tegmental area in cognitively unimpaired adults who later develop cognitive decline

Matteo De Marco, A. Venneri

18.10 Longitudinal evaluation of astrocytes activation from CAA to CAA-ri and remission: the CAA SINdem Study Group biomarker study on the  diagnostic  utility  of  YKL-40 Fabrizio Piazza

18.20 Classification accuracy of TMS for the diagnosis of neurodegenerative dementias: a multicenter study

Alberto Benussi

18.30 ASSEMBLEA DEI SOCI SINDEM

6 Novembre

13.00-14.00

SCIENTIFIC SESSION 2

Capacità e demenza: aspetti etici

promoted by SINDEM Ethics Study Group Chairpersons: Gabriella Bottini and Andrea Stracciari

13.00 La comunicazione della diagnosi di demenza Amalia Cecilia Bruni

13.20 Demenza: direttive anticipate e decisioni di fine vita Marco Annoni

13.40 Stimolazione cerebrale profonda nei pazienti cognitivamente compromessi: implicazioni etiche

Gabriella Bottini

14.00-15.40

SCIENTIFIC SESSION 3

The stroke-dementia connection

promoted by SINDEM Vascular Cognitive Impairment Study Group

Chairpersons: Alessandro Padovani and Leonardo Pantoni

14.00 The stroke-dementia connection Rajesh Kalaria

14.20 Detecting cognitive impairment in patients with acute stroke: what tools do we have in the acute and chronic phases? Emilia Salvadori

14.40 Strategies for reducing the burden of cognitive impairment related to stroke

Leonardo Pantoni

ORAL COMMUNICATIONS

Chairpersons: Giacomo Koch and Elio Scarpini

15.00 Alzheimer’s disease and vascular dementia as main cause of death in a rural south italian population: data from the Zabùt Aging Project

Roberta Baschi, E. Amodio, V. Restivo, M. Caccamo, F. Vitale,

  1. Monastero

15.10 Exploring the complex relationship between Nutrition, gUT microbiota, and BRain AgINg: the NutBrain Study protocol Federica Prinelli, F. Adorni, M. Musicco, M. Severgnini, N. Jesuthasan, E. Perdixi, C. Crespi, S. Bernini

15.20 Altered cerebellar cortical plasticity in Alzheimer’s Disease patients

Francesco Di Lorenzo, S. Bonnì, C. Caltagirone, A. Martorana, G. Koch

15.30 Mesenchymal stem cell-derived secretome fully replicate cell- mediated neuro-reparative activities in the APP/PS1 mouse model of Alzheimer’s disease

Claudia Balducci, G. Santamaria, E. Brandi, P. La Vitola,

  1. Ferrara, G. Vegliante, E. Zanier, A. Uccelli, N.  Kerlero de Rosbo, G. Forloni

15.40-16.10

SINDEM4JUNIORS: AN UPDATE FROM BRESSANONE 2020

Chairpersons: Andrea Arighi, Alberto Benussi,

Francesco di Lorenzo

15.40 Highlights from the VIII Sindem4Juniors Bressanone 2020 Marco Bozzali

15.45 Lost in space 2: Once upon a t…urning point Chiara Cerami

15.50 Amyloid-beta40 triggers neurodegeneration in patients with Alzheimer’s pathologic change according to NIA-AA Research Framework guidelines

Caterina Motta, F. Di Lorenzo, M. Assogna, E. Scaricamazza,

  1. De Lucia, C. Bonomi, G. Sancesario, G. Koch, A. Martorana

15.55 A combined RS-EEG/RS-fMRI characterization of the Alzheimer Continuum: a longitudinal study

Giordano Cecchetti, S. Basaia, C. Cividini, M. Cursi, R. Santangelo, F. Caso, F. Minicucci, G. Magnani, M. Filippi, F. Agosta

16.00 Characterization of Mixed Primary Progressive Aphasia: language, functional neuroimaging and pathological features Salvatore Mazzeo, C. Polito, S. Padiglioni, V. Berti, S. Bagnoli, G. Lombardi, I. Piaceri, M. Carraro, C. Ferrari, B. Nacmias, S. Sorbi, V. Bessi

16.05 Discussion

16.10-17.10

SYMPOSIUM

Highlighting the importance of early Alzheimer’s Disease detection

with unrestricted grant by Roche Chairperson: Lucilla Parnetti Massimo Filippi, Daniela Galimberti

17.10-18.50

SCIENTIFIC SESSION 4

Sleep and sleep-wake rhythm disturbances in cognitive decline: Sundowning as a paradigm promoted by SINDEM Sleep & BPSD Study groups Chairpersons: Elisabetta Farina and Bianca Maria Guarnieri

17.10 Dementias, genetics and sleep Sandro Sorbi

17.30 Sundowning and other circadian rhythm disturbances in Dementia: Clinical Relevance and Therapeutic Approaches Elisabetta Farina

17.50 Light therapy in Alzheimer’s disease: state of art and future directions

Raffaele Manni

ORAL COMMUNICATIONS

Chairpersons: Giuseppe Bruno and Stefano Cappa

18.10 Circadian phase tailored light therapy in Alzheimer disease: preliminary findings on sleep and cognition

Riccardo Cremascoli, D. Sparasci, G. Giusti, M. Picascia, S. Bernini, V. Rustioni, C. Ghezzi, S. Cerri, M. Terzaghi, E. Sinforiani, R. Manni

18.20 RLS, Insomnia, and OSA in postmenopausal women: the  effect on sleep, emotional profile and cognitive functioning Rosalia Silvestri, E. Vinci, C. Di Perri, I. Aricò

18.30 Eligibility of prodromal Alzheimer Disease patients  for Disease Modifying Trials: Results from a standardized clinical work-up

Salvatore Caratozzolo, A. Scalvini, A. Pilotto, B. Paghera,

  1. Turrone, S. Cocchi, Zanetti, L. Rozzini, A. Padovani

18.40 Complexity in neuropsychological assessments of cognitive impairment: A network analysis approach

Giorgia Tosi, C. Borsani, S. Castiglioni, R. Daini, M. Franceschi, D. Romano

 

7 novembre

9.00-11.00

SCIENTIFIC SESSION 5

Update on FTD

promoted by SINDEM FTD Study Group, in collaboration with Associazione Italiana Malattia Frontotemporale Chairpersons: Barbara Borroni and Vincenzo Silani

9.00     Monogenic FTD: the GENFI cohort Jonathan Rohrer

9.30     New insights in TDP43 proteinopathies Emanuele Buratti

ORAL COMMUNICATIONS

Chairpersons: Giancarlo Logroscino and Benedetta Nacmias

10.00 Frontotemporal lobar degeneration, C9orf72 expansions and disease prediction: ancestry, syndrome-specific and age at onset implications

Beatrice Costa

10.10 I was born with Alzheimer’s Disease: Clinical case and reasoning about the communication of onset in Autosomal dominant AD

Valentina Laganà, S. Curcio, M. Mirabelli, L. Bernardi, R. Maletta, R. Di Lorenzo, A. Dodich, V. Garibotto, M. Scheffler,

  1. Frisoni, A. Bruni

10.20 Noun-verb dissociation in motor neuron disease: theoretical and clinical entailments

Edoardo Nicolò Aiello , E. Aiello, C. Luzzatti, D. Pain, M. Gallucci, G. Mora

10.30 The role of methylation of the APOE gene in Alzheimer’s disease

Paola Bisceglia, E. Costantini, A. Bizzarro, G. Paroni, R. Barbano, F. Lo Vecchio, M. Urbano, C. Gravina, P. Parrella, A. Greco, C. Masullo, D. Seripa

10.40 Per2 C111G polymorphism influences cognition in Subjective Cognitive Decline and Mild Cognitive Impairment. A 7-year follow-up study

Giulia Giacomucci, V. Bessi, S. Mazzeo, S. Bagnoli, S. Padiglioni, J. Balestrini, G. Tomaiuolo, I. Piaceri, M. Carraro,

  1. Sorbi, B. Nacmias

10.50 A family with Frontotemporal Dementia due to the MAPT mutation K298E

Ginevra Giovannelli, F. Agosta, F. Bertola, V. Castelnovo, M. Filippi, C. Ferrarese, I. Appollonio, L. Tremolizzo

11.00-13.00

SCIENTIFIC SESSION 6

Research criteria for the diagnosis of prodromal DLB in the context of alpha-synucleinopaties promoted by SINDEM DLB Study Group

Chairpersons: Laura Bonanni and Annachiara Cagnin

11.00 Research criteria for the diagnosis of prodromal DLB in the context of alpha-synucleinopaties

Pietro Tiraboschi

11.20 The role of CSF analysis in the diagnosis of synucleinopahies Gianluigi Zanusso

11.40 The diagnosis of synucleinopathies is skin deep Vincenzo Donadio

ORAL COMMUNICATIONS

Chairpersons: Annachiara Cagnin and Flavio Nobili

12.00 Dysautonomia assessment aides early DLB diagnosis

Eugenia Scaricamazza, G. Nalli, V. De Lucia, C. Bonomi, M. Assogna, C. Motta, G. Koch, A. Martorana

  • Prognostic role of gut microbiota in Parkinson’s disease de novo: a 3-year prospective study

Marco Piatti, R. Cilia, E. Cereda, S. Bonvegna, C. Ferrarese,

  1. Zecchinelli, M. Barichella, G. Pezzoli

12.20 The modulation of cognitive reserve on resting functional connectivity in early Parkinson’s disease

Sonia Di Tella, M. De Marco, F. Baglio, M. Silveri, A. Venneri

12.30 Overlap between Frontotemporal Dementia and Dementia with Lewy Bodies: a Treviso Dementia (TREDEM) registry case report

Maurizio Gallucci, C. Dell’Acqua, F. Boccaletto, C. Fenoglio,

  1. Galimberti, M. Di Battista

12.40 Metabolic neural networks dynamics of neurotransmission systems in the alpha-synuclein spectrum

Giulia Carli, S. Caminiti, L. Presotto, A. Sala, A. Galbiati, A. Pilotto, L. Ferini-Strambi, A. Padovani, D. Perani

12.50 The missing allele of the APOE polymorphism: Alzheimer disease, aging, or evolution?

Filomena Lo Vecchio, P. Bisceglia, C. Gravina, M. Urbano, F. Ciccone, A. Daniele, A. Greco, D. Seripa

 CLOSING AND POSTERS AWARDS